OUR APPROACH

Designing the Next Generation of Cancer Vaccines
 
 
 
 

The Labyrinthin Antigen

A paradigm shift is currently underway on the relationship between cancer treatment markers and current cancer therapies.

The antigen Labyrinthin, recognized by the mouse monoclonal antibody MCA 44-3A6, is a prime example of such a marker because it serves as a pan-adenocarcinoma marker that is expressed on the surface of essentially all adenocarcinomas, including lung, breast, prostate, colorectal, prostate, stomach, liver, pancreatic, and ovarian cancer, but not in normal cells nor other types of cancers.

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Unique Properties

1.  Selectivity

  • Valuable pan-tumor marker for all adenocarcinoma cells

  • Labyrinthin does not express in normal, healthy, or non-adenocarcinoma cells

2.  Presence & Location

  • Anchored to the surface of tumor cell

  • Presence on cell surface makes Labyrinthin directly accessible for antibody treatment and diagnosis

3. Function

  • May play a physiological role in cancer

  • Data indicate that Labyrinthin affects normal-to-cancer progression of cell

  • Targeting a molecule that plays a part in cancer progression will more likely yield long-lasting effects compared to targeting a marker that is only a by-product of cancer

4.  Detectability

  • Presence and location of Labyrinthin is easy to monitor and track

  • Allows for monitoring of cancer treatments and tracking of metastaseses that may not show up in the clinic 

Therapeutic Approach: 

Adenocarcinomas represent over 45% of all new cancer cases and cancer deaths. There are approximately 7.9 million new adenocarcinoma patients each year.

 

Although a range of immunotherapy approaches exist, our vaccine is targeted towards Labyrinthin-based peptides because, unlike the cancer targets for current therapies, it is both a broad and selective target and it is not a normally occurring target that is overexpressed.

We founded our company to build on early monoclonal antibody and vaccine innovations to pioneer new immunotherapies while making our product candidates available to a broader patient population.​

The LabVax Platform

In 2003, we engineered one of the earliest known synthetic peptide vaccines which was approved by the WHO for a Phase I/II in-human clinical trial. Our most recent synthetic vaccine, LabVax 2.0, is a labyrinthin-based peptide complex vaccine and is specifically designed to elicit both a humoral immune response (B-Cell) and a cell mediated immune response (T-Cell).

 

The idea is for the body to engage its own immune system to produce antibodies that target and locate Labyrinthin-positive cancer cells to initiate a process that both prevents tumor growth and kill existing tumor cells.

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Synthetic Peptide Vaccines

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